Inducible RNAi
From WikiCover
On August 2, 2007, Open Biosystems announced the release of the newest generation of shRNAmir libraries with its Expression Arrest TRIPZ inducible lentiviral shRNAmir library for RNAi. Targeting the entire human genome with multiple shRNAmir constructs per gene, the TRIPZ inducible lentiviral shRNAmir library builds on Open Biosystems' proven vector-based RNAi technologies that enable researchers to quickly realize the inherent value of vector-based RNAi. This offering for inducible RNAi, the first of its kind, allows for rapid validation of drug targets by the creation of in vivo animal models, a necessary step in the drug discovery process.
The TRIPZ library consists of shRNAmir constructs that have been pre-cloned into a Tetracycline-inducible lentiviral vector, resulting in a powerful RNAi trigger that expands the potential of RNAi to cell and animal models previously refractory to RNAi. Open Biosystems' TRIPZ shRNAmir provides researchers and scientists with options for tightly regulated RNAi and increased delivery range into a vast number of cell types from primary and non-dividing cells to in vivo animal models.
Expression Arrest human TRIPZ lentiviral shRNAmir is available immediately as individual shRNAmir constructs, target gene sets or a whole genome library subscription.